Vaccines are an important tool to help prevent the spread of infectious diseases like COVID-19. Despite their importance, it can be difficult to get such important medicine to everybody who needs it. We developed a painless vaccine patch that can make vaccines easier to transport. It could also increase access for everyone, especially those who are scared of needles! In this study, we wanted to determine if our vaccine patch could produce an immune response, increasing our bodies’ protection. We measured the amount of antibodies produced by the immune systems in mice who received the vaccine patch and showed that this vaccine tool is just as effective as traditional needle vaccinations. We also found that the vaccine patch protected the mice from COVID-19 after a single application. These discoveries proved that the vaccine patch can be a safe and effective form of delivering vaccinations.