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Abstract

Normally, the tissue that makes up each of your body’s organs only grows in the place it should. But that’s not the case for people with endometriosis. With this disease, tissue that lines the uterus grows outside the uterus as lesions. These cause pain and infertility. Endometriosis affects about 10% of women worldwide as well as some trans people. On very rare occasions it has been detected in men. 

Scientists know that people with endometriosis have high levels of a type of white blood cell called macrophages. We wanted to find out how macrophages affected the growth of lesions as well as pain in people with endometriosis. So, we studied mice with endometriosis in a laboratory. We changed the number and type of macrophages present in the mice to learn how these cells affect the development of lesions. We discovered that certain types of macrophages may help to treat endometriosis. Others encourage the development of lesions. Our findings could lead to new treatments for endometriosis patients!

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About this article

Reading level
Scientific topic
Key words
NGSS standards
AP Environmental science topics
IB Biology topics
Scientific methods
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Scientist Affiliation
Publication date
April 2024

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